| Title | Influence of heat treatment on spray-dried mixtures of Amioca((R)) starch and Carbopol((R)) 974P used as carriers for nasal drug delivery. | | Author(s) | Coucke D, Pringels E, Foreman P, Adriaensens P, Carleer R, Remon JP, Vervaet C | | Institution | Laboratory of Pharmaceutical Technology, Ghent University, Harelbekestraat 72, B-9000 Ghent Belgium. | | Source | Int J Pharm 2009 May 25. | | Abstract | A mucoadhesive spray-dried starch/poly(acrylic acid) powder underwent different heat treatments in order to induce crosslinking between the functional groups of starch (Amioca((R))) and poly(acrylic acid) (Carbopol((R)) 974P). After heat treatment the water-absorbing capacity, viscosity and elasticity of the muco-adhesive powder increased. NMR analysis in combination with FT-IR indicated that heat treatment induced a low degree of cross-linking between the polymers. Nasal administration of Amioca((R))/Carbopol((R)) 974P powders without heat treatment resulted in an absolute bioavailability in rabbits of 8.2+/-3.0% for insulin. Due to the difference in water-absorbing capacity (which opened the tight junctions of the nasal mucosa), elasticity and plasticity (which reduced mucociliairy clearance and prolonged residence time) heat treatment at 120 degrees C improved the bioavailability: 26.4+/-21.9, 36.5+/-11.0 and 19.3+/-17.3% after heat treatment during 30min, 1h and 4h, respectively. Heat treatment at 60 degrees C was less efficient. This study demonstrated that the nasal insulin absorption improved via heat treatment of the Amioca((R))/Carbopol((R)) 974P powder (prior to the addition of insulin). The bioavailability-enhancing effect of a 1h heat treatment at 120 degrees C was confirmed using the same polymer matrix in combination with different drugs (salmon calcitonin, human growth hormone and metoprolol tartrate). | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19477256 |
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