| Title | Cleft soft palate reconstruction: prospective study on infection and antibiotics. | | Author(s) | Mÿburgh HP, Bütow KW | | Institution | Department of Maxillo- Facial and Oral Surgery, University of Pretoria, South-Africa. | | Source | Int J Oral Maxillofac Surg 2009 May 28. | | Abstract | The aim of this prospective study was to identify possible pathogenic organisms associated with wound complications in the form of wound infections, wound breakdown and the formation of oro-nasal fistulas. The organisms' resistance profile to antibiotics was also evaluated. This prospective study consisted of the evaluation of the intra-oral microbiological profile of 100 babies with soft palate cleft deformities peri-operatively. A wide spectrum of pathogenic organisms from the upper aero-digestive track was isolated, as well as a group of organisms that originated from the colon/perineum. The latter organisms were mostly associated with postoperative complications. The antibiotic resistance profile showed a high resistance to commonly used antibiotics such as ampicillin, amoxycillin-clavulanic acid, and first- and second-generation cephalosporins. The resistance profile of the organisms needs to be reassessed and appropriate antibiotics must be used in combination with an antimicrobial mouth rinse. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19481905 |
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