Effect of parenteral cladribine on relapse rates in patients with relapsing forms of multiple sclerosis: results of a 2-year, double-blind, placebo-controlled, crossover study. Multiple sclerosis (Houndmills, Basingstoke, England) [Mult Scler] Journal article | | Title | Effect of parenteral cladribine on relapse rates in patients with relapsing forms of multiple sclerosis: results of a 2-year, double-blind, placebo-controlled, crossover study. | | Author(s) | Stelmasiak Z, Solski J, Nowicki J, Jakubowska B, Ryba M, Grieb P | | Institution | Department of Neurology, Medical University of Lublin, Lublin, Poland. | | Source | Mult Scler 2009 Jun; 15(6):767-770. | | Abstract | ObjectiveThis randomized, 2-year, double-blind, placebo-controlled, crossover study evaluated cladribine for relapsing forms of multiple sclerosis.Design
PATIENTS: (n = 84) received seven 5-day courses of subcutaneous cladribine at 5 mg/day (group A) or placebo (group B) in year 1; treatment was reversed in year 2.ResultsCladribine was well tolerated and associated with a favorable safety profile. Mean Expanded Disability Status Scale scores remained stable. In group A, mean relapse rates were 0.15 in year 1 (cladribine) and 0.42 in year 2. In group B, relapse rates were 0.61 in year 1 and 0.50 in year 2 (cladribine). Patients required fewer steroid courses during cladribine periods. The therapeutic efficacy of cladribine was associated with a sustained reduction in lymphocyte count. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19482866 |
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