| Title | Syndrome of Inappropriate Antidiuretic Hormone Secretion Possibly Associated With Amantadine Therapy in Parkinson Disease. | | Author(s) | Alonso Navarro H, Sánz-Aiz A, Izquierdo L, Jiménez Jiménez FJ | | Institution | From the *Department of Medicine-Neurology, Hospital "Príncipe de Asturias," Universidad de Alcalá, Alcalá de Henares, Madrid; daggerSection of Neurology, Complejo La Mancha-Centro, Alcázar de San Juan, Ciudad Real; double daggerDepartment of Internal Medicine, Hospital "Príncipe de Asturias," Universidad de Alcalá, Alcalá de Henares; and section signSection of Neurology, Hospital del Sureste, Arganda del Rey, Madrid, Spain. | | Source | Clin Neuropharmacol 2009 May/June; 32(3):167-168. | | Abstract | OBJECTIVES:: To report a patient who developed a syndrome of inappropriate antidiuretic hormone secretion (SIADH) related with amantadine therapy.
CASE REPORT:: A 66-year-old woman, diagnosed with Parkinson disease, developed asthenia, anorexia, weight loss, lethargy and feeling of muscle weakness, and severe hyponatremia, with diagnostic criteria for SIADH, after exposure to amantadine. After amantadine withdrawal, these symptoms disappeared, and sodium levels reached normal values gradually.
CONCLUSIONS:: The SIADH should be taken into account among the possible side effects of amantadine. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19483487 |
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