Submacular combination treatment for management of acute, massive submacular hemorrhage in age-related macular degeneration. Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye [Ophthalmic Surg Lasers Imaging] Journal article | | Title | Submacular combination treatment for management of acute, massive submacular hemorrhage in age-related macular degeneration. | | Author(s) | Shah SP, Hubschman JP, Gonzales CR, Schwartz SD | | Institution | Jules Stein Eye Institute, Department of Ophthalmology University of California, David Geffen School of Medicine, Los Angeles, California 90095, USA. | | Source | Ophthalmic Surg Lasers Imaging 2009 May-Jun; 40(3):308-15. | | MeSH | Acute Disease
Aged
Aged, 80 and over
Angiogenesis Inhibitors
Antibodies, Monoclonal
Aptamers, Nucleotide
Combined Modality Therapy
Drug Therapy, Combination
Female
Fibrinolytic Agents
Fluorescein Angiography
Humans
Macular Degeneration
Male
Recombinant Proteins
Retinal Hemorrhage
Tissue Plasminogen Activator
Tomography, Optical Coherence
Vascular Endothelial Growth Factor A
Visual Acuity
Vitrectomy
| | Abstract | A surgical technique is described combining submacular anti-vascular endothelial growth factor (anti-VEGF) and recombinant tissue plasminogen activator (r-TPA) with pneumatic displacement of massive submacular hemorrhage in age-related macular degeneration. An 84-year-old man with a large, acute submacular hemorrhage secondary to age-related macular degeneration underwent combination vitrectomy, submacular anti-VEGF and r-TPA injection with pneumatic displacement of the hemorrhage. At the last follow-up visit, 7 months after surgery, visual acuity was 20/80 with a small fibrovascular pigment epithelial detachment and atrophic retinal pigment epithelial changes. A 77-year-old woman with known age-related macular degeneration underwent a similar surgical procedure for a similar acute, large submacular hemorrhage related to age-related macular degeneration. Nine months after surgery, the visual acuity was 20/70(-1). Combination submacular anti-VEGF therapy delivered at the time of pars plana vitrectomy and submacular tissue plasminogen activator assisted hemorrhage displacement may be a viable treatment strategy for the management massive submacular hemorrhage. | | Language | eng | | Pub Type(s) | Case Reports
Journal Article
| | PubMed ID | 19485299 |
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