| Title | The stage of offspring of female rats after treatment with cytostatics of various groups. | | Author(s) | Borovskaya TG, Perova AV, Pachomova AV, Poluektova ME, Gol'dberg VE | | Institution | Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia. mmu@pharm.tsu.ru | | Source | Bull Exp Biol Med 2008 Oct; 146(4):429-32. | | Abstract | We examined the offspring of female rats that were mated with intact males in the delayed period after administration of cytostatic drugs Farmorubicin, platidiam, carboplatin, etoposide, and paclitaxel (1, 3, and 6 months post-treatment). Toxicity of these drugs in the offspring decreased in the following order: paclitaxel > etoposide > carboplatin > platidiam > Farmorubicin. The toxic effect depended not only on the type of cytostatic treatment, but also on the period of conception. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19489312 |
|
