PREFERENTIAL HYPERACUITY PERIMETRY TO DETECT HYDROXYCHLOROQUINE RETINAL TOXICITY. Retina (Philadelphia, Pa.) [Retina] Journal article | | Title | PREFERENTIAL HYPERACUITY PERIMETRY TO DETECT HYDROXYCHLOROQUINE RETINAL TOXICITY. | | Author(s) | Anderson C, Pahk P, Blaha GR, Spindel GP, Alster Y, Rafaeli O, Marx JL | | Institution | From the *Department of Ophthalmology, Lahey Clinic, Peabody, Massachusetts; daggerSpindel Eye Associates, Derry, New Hampshire; and double daggerNotal Vision, Tel Aviv, Israel. | | Source | Retina 2009 May 27. | | Abstract | PURPOSE:: To determine if Preferential Hyperacuity Perimetry (PHP) testing can detect the presence of retinal toxicity due to hydroxychloroquine (HCQ) or chloroquine administration.
METHODS:: Fifteen patients were divided into three groups. Five patients had confirmed HCQ or chloroquine toxicity, five patients had suspected HCQ toxicity, and five patients had history of long-term use of HCQ or chloroquine but no evidence of toxicity. All patients underwent PHP testing.
RESULTS:: All patients with either known or suspected toxicity based upon standardized visual field testing and/or fluorescein angiography demonstrated significant hyperacuity defects on PHP testing. None of the patients on long-term HCQ therapy, without clinical suspicion of toxicity, demonstrated a PHP hyperacuity defect.
CONCLUSIONS:: Results of this pilot study with patients with known or suspected HCQ or chloroquine toxicity suggest that PHP may be a useful adjunct for testing of patients suspicious for toxicity due to these medications. Further testing is warranted. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19491724 |
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