| Title | Diphenhydramine as a topical ocular anesthetic. | | Author(s) | Suffridge PJ, Wiggins MN, Landes RD, Harper RA | | Source | Can J Ophthalmol 2009 Apr; 44(2):181-4. | | Abstract | Objective: To determine whether 5% diphenhydramine solution has an anesthetic effect when administered topically to rabbit corneas.
Design: Experimental study.
Participants: Twenty white New Zealand rabbits.
Methods: Twenty rabbits at the University of Arkansas for Medical Sciences received 1 drop of 5% diphenhydramine solution in the left eye and 1 drop of balanced salt solution in the right eye. Corneal sensation was then measured with a Cochet-Bonnet esthesiometer at 30-, 60-, and 90-minute intervals. Rabbits were observed for conjunctival reaction. Follow-up fluorescein and Rose Bengal slit-lamp examinations were then performed to assess toxicity.
Results: Diphenhydramine solution at a 5% concentration demonstrated a significant anesthetic effect 30, 60, and 90 minutes after instillation (p < 0.0001, p = 0.0001, p = 0.0164, respectively). Mild conjunctival injection occurred in all diphenhydramine-treated eyes. No toxic effects on the corneal epithelium were observed.
Conclusions: When applied topically to rabbit corneas, 5% diphenhydramine solution has a significant anesthetizing effect compared with salt solution (control eyes). Topical diphenhydramine may be a safe alternative in patients requiring topical anesthesia who have multiple allergies to topical anesthetics. Additional studies are needed to determine a dose-response curve and to further evaluate corneal toxicity prior to use in humans. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19491952 |
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