| Title | Mycobacterium tuberculosis: drug resistance and future perspectives. | | Author(s) | Riccardi G, Pasca MR, Buroni S | | Institution | Department of Genetics & Microbiology, University of Pavia, Via Ferrata, 1 27100 Pavia, Italy. riccardi@ipvgen.unipv.it. | | Source | Future Microbiol 2009 Jun.:597-614. | | Abstract | TB is still a global health problem. The selection and spread of multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis strains represents a threat for global TB control. The reappearance of TB has driven an increased interest in understanding the mechanisms of drug action and drug resistance, which could provide a significant contribution in the development of new antimicrobials. In this article, the authors describe the mode of action and the resistance mechanisms of the principal first- and second-line antitubercular agents, namely isoniazid, ethionamide, ethambutol, D-cycloserine, rifamycins, fluoroquinolones, streptomycin, linezolid and pyrazinamide. A brief outline of the seven drugs in clinical development is reported, showing how the development of new TB drugs is still required. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19492969 |
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