Acetazolamide suppresses the prevalence of augmented breaths during exposure to hypoxia. American journal of physiology. Regulatory, integrative and comparative physiology [Am J Physiol Regul Integr Comp Physiol] Journal article | | Title | Acetazolamide suppresses the prevalence of augmented breaths during exposure to hypoxia. | | Author(s) | Bell HJ, Haouzi P | | Institution | Penn State University, College of Medicine. | | Source | Am J Physiol Regul Integr Comp Physiol 2009 Jun 3. | | Abstract | Augmented breaths, or 'sighs', commonly destabilize respiratory rhythm, precipitating apneas and variability in the depth and rate of breathing, which may then exacerbate sleep disordered breathing in vulnerable individuals. We have previously demonstrated that hypocapnia is a unique condition associated with a high prevalence of augmented breaths during exposure to hypoxia; the prevalence of augmented breaths during hypoxia can be returned to normal by simply providing supplemental CO2 into the inspired air. We hypothesized that counteracting the effect of respiratory alkalosis during hypocapnic-hypoxia by blocking carbonic anhydrase would yield a similar effect. We therefore investigated the effect of acetazolamide treatment on the prevalence of augmented breaths in the resting breathing cycle in 5 awake, adult male rats. We found that exposure to hypocapnic-hypoxia led to a 475% increase in the prevalence of augmented breaths compared to room air conditions. Acetazolamide treatment (100 mgkg(-1) IP, bid) for 3 days resulted in a rapid and potent suppression of the generation of augmented breaths during hypoxia. Within 90 minutes of the first dose, the prevalence of augmented breaths in hypoxia fell to levels that were no greater than those observed in room air. Upon cessation of treatment, exposure to hypocapnic-hypoxia once again caused a large increase in the prevalence of augmented breaths. These results reveal a novel means by which acetazolamide treatment acts to stabilize breathing, and may help to explain the beneficial effects of the drug on breathing stability at altitude and in patients with central forms of sleep disordered breathing. Key words: Sighs, acidosis, alkalosis, respiratory instability. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19494178 |
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