Recurrent partial hydatidiform mole, with a first twin pregnancy, after treatment with clomiphene citrate. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology [Gynecol Endocrinol] Journal article | | Title | Recurrent partial hydatidiform mole, with a first twin pregnancy, after treatment with clomiphene citrate. | | Author(s) | Tica AA, Tica OS, Georgescu CV, Mixich F, Tica VJ, Berceanu S, Ebanca E, Patrascu A, Simionescu C | | Institution | Department of Pharmacology, University of Medicine and Pharmacy Craiova, Craiova, Dolj, Romania. | | Source | Gynecol Endocrinol 2009 Jun 2.:1-6. | | Abstract | We present a patient, treated for 3 months with clomiphen citrate after 5 years of infertility. This treatment resulted in a twin pregnancy, one degenerated into a partial hydatidiform mole and the other into a very early embryo death. The karyotype was a mosaic one: 63% of metaphases showed triploidy - 69 XXX and 37% diploidy - 46 XX. Despite all medical advice, she returned 8 months later with a new pregnancy, which proved to be a new partial hydatidiform mole, this time a single one. Karyotype was, also, a triploidy - 69 XXX. The genetic map of both genitors was performed, showing no aberrations. Unfortunately, the patient came back, once again, 5 months later, with a new positive pregnancy test. Ultrasonography revealed a new very early embryo death, the histopathological analysis establishing to be a single 'pure' stop in evolution of the pregnancy. As all the three pregnancies obtained after treatment with clomiphene were abnormal, two being partial hydatidiform moles and one being a premature miscarriage, without any genetic aberrations of the genitors, it seems very possible that clomiphene, apart from improving fertility, also increases the risk of abnormal ovum appearance. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19499414 |
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