Li Q, Wang X, Lu X, Tian H, Jiang H, Lv G, Guo D, Wu C, Chen B
The incorporation of daunorubicin in cancer cells through the use of titanium dioxide whiskers. [JOURNAL ARTICLE]
Biomaterials 2009 Jun 3.
Porous nanostructure with its unique properties is found to be able to hold promise in drug delivery. We fabricated the one-dimensional titanium dioxide whiskers (TiO(2) Ws) and designed a strategy to explore their drug delivery application and anti-tumor function combined with daunorubicin (DNR). We observed good biocompatibility of TiO(2) Ws and noted better photocatalytic activity. In human hepatocarcinoma cells (SMMC-7721 cells), TiO(2) Ws can obviously increase the intracellular concentration of DNR and enhance its potential anti-tumor efficiency, indicating TiO(2) Ws could produce an efficient drug delivery carrier effect importing DNR into target cells. Furthermore, its photocatalysis further led to the enhanced mortality of cancer cells under UV irradiation. These findings reveal that TiO(2) Ws-based delivery of anticancer drugs represents a promising approach in cancer therapy.
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