Iloprost, a prostacyclin (PGI2) analogue, reduces liver injury in hepatic ischemiareperfusion in rats. Acta cirúrgica brasileira / Sociedade Brasileira para Desenvolvimento Pesquisa em Cirurgia [Acta Cir Bras] Journal article | | Title | Iloprost, a prostacyclin (PGI2) analogue, reduces liver injury in hepatic ischemiareperfusion in rats. | | Author(s) | Gedik E, Girgin S, Obay BD, Ozturk H, Ozturk H, Buyukbayram H | | Institution | Department of General Surgery, Medical School, Dicle University, Diyarbakir, Turkey. | | Source | Acta Cir Bras 2009 May-Jun; 24(3):226-32. | | Abstract | PURPOSE: To evaluate the effects of iloprost a prostacyclin analogue on the hepatic IR injury in rats.
METHODS: Forty male Sprague-Dawley rats (250-300 g) were divided into four groups each containing 10 rats;(1)- controls: data from unmanipulated animals; (2) sham group: rats subjected to the surgical procedure, except for liver I/R, and given saline; (3) I/R group: rats that underwent liver ischemia for 45 min followed by reperfusion for 45 min; (4) IR/ Iloprost group: rats pretreated with iloprost (10 microg kg-1, i.v). Liver tissues were taken to determine SOD, CAT, GSH, and MDA levels and for biochemical and histological evaluation.
RESULTS: The plasma ALT and AST levels were increased in group 3 than in group 4. MDA values and the liver injury score decreased, while the SOD, CAT, and GSH values increased in group 4 compared to group 3. In group 3, hepatocytes were swollen with marked vacuolization. In group 4, there were regular sinusoidal structures with normal morphology without any signs of congestion.
CONCLUSION: We demonstrated hepatoprotective effects of iloprost against severe ischemia and reperfusion injury in rat liver. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19504007 |
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