Emergence of High Levels of Extended-Spectrum {beta}-lactamase-producing Gram-negative Bacilli in Asia/Pacific: Data from SMART 2007. Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] Journal article

Of 3,004 Gram-negative bacilli collected from intra-abdominal infections in the Asia/Pacific region during 2007, 42.2% and 35.8% of Escherichia coli and Klebsiella spp., respectively, were extended-spectrum beta-lactamase (ESBL)-positive. Moreover ESBL rates in India for E. coli, K. pneumoniae and K. oxytoca were 79.0%, 69.4% and 100%, respectively. ESBL-positive E. coli rates were also relatively high in China (55.0%) and Thailand (50.8%). Ertapenem and imipenem were the most active drugs tested, inhibiting over 90% of all species including ESBL-positive isolates with the exception of Pseudomonas aeruginosa (<90% susceptible to all study drugs) and ESBL-positive K. pneumoniae (<90% susceptible to all study drugs except impenem). Quinolones achieved 90% inhibition levels only against ESBL-negative K. pneumoniae and ESBL-negative K. oxytoca. The decline in ampicillin-sulbactam activity is noted with only 34.5% of all Enterobacteriaceae inhibited in this study.

Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother]