| Title | Emergence of High Levels of Extended-Spectrum {beta}-lactamase-producing Gram-negative Bacilli in Asia/Pacific: Data from SMART 2007. | | Author(s) | Hawser SP, Bouchillon SK, Hoban DJ, Badal RE, Hsueh PR, Paterson D | | Institution | International Health Management Associates Europe Sàrl, 1066 Epalinges, Switzerland; International Health Management Associates, Inc., Schaumburg, IL 60173-3817, USA; Departments of Laboratory Medicine and Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan; University of Queensland, Brisbane, Australia. | | Source | Antimicrob Agents Chemother 2009 Jun 8. | | Abstract | Of 3,004 Gram-negative bacilli collected from intra-abdominal infections in the Asia/Pacific region during 2007, 42.2% and 35.8% of Escherichia coli and Klebsiella spp., respectively, were extended-spectrum beta-lactamase (ESBL)-positive. Moreover ESBL rates in India for E. coli, K. pneumoniae and K. oxytoca were 79.0%, 69.4% and 100%, respectively. ESBL-positive E. coli rates were also relatively high in China (55.0%) and Thailand (50.8%). Ertapenem and imipenem were the most active drugs tested, inhibiting over 90% of all species including ESBL-positive isolates with the exception of Pseudomonas aeruginosa (<90% susceptible to all study drugs) and ESBL-positive K. pneumoniae (<90% susceptible to all study drugs except impenem). Quinolones achieved 90% inhibition levels only against ESBL-negative K. pneumoniae and ESBL-negative K. oxytoca. The decline in ampicillin-sulbactam activity is noted with only 34.5% of all Enterobacteriaceae inhibited in this study. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19506060 |
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