| Title | Laboratory Diagnosis and Molecular Basis of Mild von Willebrand Disease Type 1. | | Author(s) | Michiels JJ, Berneman Z, Gadisseur A, van der Planken M, Schroyens W, van Vliet HH | | Institution | Hemostasis and Thrombosis Research Center, Antwerp University Hospital, Edegem, Belgium. | | Source | Acta Haematol 2009; 121(2-3):85-97. | | Abstract | Mild type 1 von Willebrand disease (VWD) is characterized by low to variable penetrance of bleeding, a high (increased) prevalence of blood group O, von Willebrand factor (VWF) values around and above 30% with normal ratios of VWF:ristocetin cofactor activity (RCo)/VWF:antigen (Ag), VWF:collagen binding (CB)/VWF:Ag and factor VIII (FVIII):coagulant activity (C)/VWF:Ag. Within this group of patients, the combination of the C1584 mutation and blood group O is rather frequent. Patients with mild VWD type 1 present good/normal responses of FVIII:C and VWF parameters to desmopressin (DDAVP). With the exclusion of dominant VWD type Vicenza, type 1/2E, recessive 2N and dominant 2M, missense mutations in patients with mild VWD type 1 with normal multimers are mainly located in the regulatory sequence region, the D1/D2 propeptide region, the D' VWF-FVIII binding site region and the D4, B1-B3 and C1-C2 domains but rarely in the D3, A1 or A2 domain. A new category of either dominant or recessive mild VWD type 1 due to mutations in the D4, B1-B3 and C1-C2 domains of the VWF gene consists of two groups: one group with mild VWD with normal VWF multimers and a second group with mild/moderate VWD with smeary multimer pattern. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19506353 |
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