Mizuno T, Kondo M, Ishigami N, Tamura A, Itsukage M, Koizumi H, Isayama R, Hosomi A, Nagakane Y, Tokuda T, Sugimoto E, Ushijima Y, Nakagawa M
Cognitive Impairment and Cerebral Hypoperfusion in a CADASIL Patient Improved During Administration of Lomerizine. [Journal Article]
Clin Neuropharmacol 2009 Mar-Apr; 32(2):113-6.
A 64-year-old woman was admitted to our hospital for recurrent stroke and cognitive impairment and was diagnosed with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Iodine-123 iodoamphetamine single photon emission computed tomography showed hypoperfusion in the whole brain, but cerebral blood flow increased dramatically after the administration of acetazolamide in the cerebral cortex. Lomerizine, a diphenylmethylpiperazine Ca channel blocker, can selectively increase cerebral blood flow. Cognitive decline and cerebral hypoperfusion improved during 2-year administration of lomerizine in this CADASIL patient, and thus, lomerizine is a potential candidate for treating cognitive impairment in CADASIL patients.
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