Lopatina EV, Karetsky AV, Penniyaynen VA, Vinogradova TV
Role of Cardiac Glycosides in Regulation of the Growth of Retinal Tissue Explants. [JOURNAL ARTICLE]
Bull Exp Biol Med 2008 Dec; 146(6):744-746.
We studied the role of cardiac glycosides in the regulation of the growth of retinal tissue explants from 10-12-day-old chicken embryos in organotypic culture. The studied compounds produced a dose-dependent effect on cell proliferation in retinal tissue explants. Ouabain (10(-13)M), strophanthin K (10(-13)M) and digoxin (10(-11)M) significantly stimulated explant growth. It was hypothesized that the physiological role of endogenous oubain is associated with regulation of tissue modeling.
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