| Title | Role of Cardiac Glycosides in Regulation of the Growth of Retinal Tissue Explants. | | Author(s) | Lopatina EV, Karetsky AV, Penniyaynen VA, Vinogradova TV | | Institution | Department of Experimental Pharmacology of V. A. Almazov Federal Heart, Blood and Endocrinology Center; Phtysioophtalmology group, Saint-Petersburg Institute of Phtysiopulmonology; Laboratory for physiology of excitable membranes of I. P. Pavlov Institute of Physiology, Saint-Petersburg, Russia. evl1112@infran.ru. | | Source | Bull Exp Biol Med 2008 Dec; 146(6):744-746. | | Abstract | We studied the role of cardiac glycosides in the regulation of the growth of retinal tissue explants from 10-12-day-old chicken embryos in organotypic culture. The studied compounds produced a dose-dependent effect on cell proliferation in retinal tissue explants. Ouabain (10(-13)M), strophanthin K (10(-13)M) and digoxin (10(-11)M) significantly stimulated explant growth. It was hypothesized that the physiological role of endogenous oubain is associated with regulation of tissue modeling. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19513372 |
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