| Title | Effects of cholinotropic and cytostatic drugs on the development of arthus reaction. | | Author(s) | Nezhinskaya GI, Sapronov NS, Vladykin AL, Shepeleva VV | | Institution | S. V. Anichkov Department of Neuropharmacology, Institute of Experimental Medicine, the Russian Academy of Medical Sciences, St. Petersburg, Russia. sns@iem.spb.ru. | | Source | Bull Exp Biol Med 2008 Dec; 146(6):747-9. | | Abstract | Antimuscarinic effects of ipratropium bromide and atropine are associated with prevention of the development of Arthus reaction, while the cytostatic effects of cyclophosphamide and doxorubicin lead to involution of the thymus and spleen, suppression of antibody production, and aggravation of inflammation, which causes edema of the ankle joint (cyclophosphamide treatment). Apoptosis of tumor cell and inhibition of inflammation can be essential for chemotherapy of malignant and autoimmune diseases. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19513373 |
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