| Title | Nanocrystalline titanium dioxide and magnesium oxide in vitro dermal absorption in human skin. | | Author(s) | van der Merwe D, Tawde S, Pickrell JA, Erickson LE | | Institution | Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, Kansas 66506, USA. dmerwe@vet.ksu.edu | | Source | Cutan Ocul Toxicol 2009; 28(2):78-82. | | Abstract | The dermal absorption potential of a nanocrystalline magnesium oxide (MgO) and titanium dioxide (TiO(2)) mixture in dermatomed human skin was assessed in vitro using Bronaugh-type flow-through diffusion cells. Nanocrystalline material was applied to the skin surface at a dose rate of 50 mg/cm(2) as a dry powder, as a water suspension, and as a water/surfactant (sodium lauryl sulfate) suspension, for 8 hours. Dermal absorption of nanocrystalline MgO and TiO(2) through human skin with intact, functional stratum corneum was not detectable under the conditions of this experiment. | | Language | eng | | Pub Type(s) | Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
| | PubMed ID | 19514931 |
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