| Title | Enhanced transdermal delivery of loratadine from the EVA matrix. | | Author(s) | Cho CW, Choi JS, Kim SJ, Shin SC | | Institution | College of Pharmacy, Chungnam National University, Daejeon, South Korea. | | Source | Drug Deliv 2009 May; 16(4):230-5. | | Abstract | Various enhancers, such as fatty acids (saturated, unsaturated), glycerides, propylene glycols, and non-ionic surfactants, have been incorporated in the loratadine-EVA matrix to increase the rate of skin permeation of loratadine from an EVA matrix. The enhancing effects of these enhancers on the skin permeation of loratadine were evaluated using a modified Keshary-Chien cell fitted with intact excised rat skin. The penetration enhancers showed a higher flux, probably due to the enhancing effect on the skin barrier, the stratum corneum. Among the enhancers used, such as the fatty acids, glycols, propylene glycols, and non-ionic surfactants, linoleic acid showed the best enhancement. For the enhanced transdermal delivery of loratadine, application of an EVA matrix containing a permeation enhancer might be useful in the development of a transdermal drug delivery system. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19514983 |
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