| Title | Luteal support with intravaginal progesterone increases clinical pregnancy rates in women with polycystic ovary syndrome using letrozole for ovulation induction. | | Author(s) | Montville CP, Khabbaz M, Aubuchon M, Williams DB, Thomas MA | | Institution | Division of Reproductive Endocrinology, Center for Reproductive Health, Department of Obstetrics and Gynecology, University of Cincinnati, Cincinnati, Ohio. | | Source | Fertil Steril 2009 Jun 8. | | Abstract | OBJECTIVE: To determine the effect of intravaginal micronized P on pregnancy rates in clomiphene citrate and letrozole ovulation induction cycles in women with polycystic ovary syndrome (PCOS).
DESIGN: Retrospective chart review.
SETTING: University-based assisted reproductive technology program.
PATIENTS: Women with PCOS who underwent ovulation induction with either clomiphene citrate (n = 90) or letrozole (n = 31) from January 2002 to December 2008.
INTERVENTION(S): Clomiphene citrate (50-250 mg x 5 days) or letrozole (5 mg x 5 days) were used for ovulation induction. After either intercourse or IUI, patients received intravaginal micronized P (200 mg twice daily) according to prescribing physician preference.
MAIN OUTCOME MEASURE(S): Clinical pregnancy rate.
RESULT(S): In clomiphene cycles, clinical pregnancies were documented in 15.3% of cycles (19 of 124) in the P group, compared with 12.1% (11 of 91) of the non-P group. In letrozole cycles, clinical pregnancies were documented in 21.1% of cycles (8 of 38) in the P group, compared with none (0 of 13) in the non-P group.
CONCLUSION(S): Women with PCOS who used letrozole for ovulation induction had higher clinical pregnancy rates when using intravaginal P support. Luteal supplementation with P should be strongly considered in women with PCOS, especially in those using letrozole for ovulation induction. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19515366 |
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