| Title | Novel application of plasma treatment for pharmaceutical and biomedical engineering. | | Author(s) | Kuzuya M, Sasai Y, Kondo S, Yamauchi Y | | Institution | Department of Pharmaceutical Physical Chemistry, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan. mkuzuya@cc.matsuyama-u.ac.jp. | | Source | Curr Drug Discov Technol 2009 Jun; 6(2):135-50. | | Abstract | The nature of plasma-induced surface radicals formed on a variety of organic polymers has been studied by electron spin resonance (ESR), making it possible to provide a sound basis for future experimental design of polymer surface processing using plasma treatment. On the basis of the findings from such studies, several novel bio-applications in the field of drug- and biomedical- engineering have been developed. Applications for drug engineering include the preparation of reservoir-type drug delivery system (DDS) of sustained- and delayed-release, and floating drug delivery system (FDDS) possessing gastric retention capabilities, followed by preparation of "Patient-Tailored DDS". Furthermore, the preparation of composite powders applicable to matrix-type DDS was developed by making a mechanical application to the surface radical-containing polymer powders with drug powders. In applications for biomedical engineering, the novel method to introduce the durable surface hydrophilicity and lubricity on hydrophobic biomedical polymers was developed by plasma-assisted immobilization of carboxyl group-containing polymer on the polymer substrate. The surfaces thus prepared were further used for the covalent immobilization of oligo-nucleotides (DNA) onto the polymer surfaces applicable to constructing DNA diagnosis system, and also plasma-assisted preparation of functionalized chemo-embolic agent of vinyl alcohol-sodium acrylate copolymer (PVA- PAANa). | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19519338 |
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