Endothelial dysfunction in patients with obstructive sleep apnoea independent of metabolic syndrome. Annals of the Academy of Medicine, Singapore [Ann Acad Med Singapore] Journal article | | Title | Endothelial dysfunction in patients with obstructive sleep apnoea independent of metabolic syndrome. | | Author(s) | Amra B, Karbasi E, Hashemi M, Hoffmann-Castendiek B, Golshan M | | Institution | Isfahan University of Medical Sciences, Sheikh Mofid St 8164763831, Isfahan, Iran. amra@med.mui.ac.ir | | Source | Ann Acad Med Singapore 2009 May; 38(5):461-4. | | Abstract | INTRODUCTION: Obstructive sleep apnoea syndrome (OSAS), characterised by intermittent hypoxia/re-oxygenation, has been identified as an independent risk factor for cardiovascular diseases and endothelial dysfunction. Our aim was to investigate flow-mediated dilatation (FMD) in patients with obstructive sleep apnoea with and without metabolic syndrome.
MATERIALS AND METHODS: Fifty-two subjects with OSAS diagnosed by polysomnography were classified into 2 groups according to the presence and absence of the metabolic syndrome and also according to the severity: mild to moderate OSAS group and severe OSAS group. Endothelial function of the brachial artery was evaluated by using high-resolution vascular ultrasound. Endothelial-dependent dilatation (EDD) was assessed by establishing reactive hyperaemia and endothelial-independent dilatation (EID) was determined by using sublingual isosorbide dinitrate. Spearman correlation and regression analysis were performed.
RESULTS: EDD was not significantly different in patients with OSAS and metabolic syndrome as compared with OSAS without metabolic syndrome (4.62 +/- 0.69 versus 4.49 +/- 0.93, P >0.05).
CONCLUSIONS: Endothelial dysfunction in OSA may be independent of metabolic syndrome. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19521652 |
|
|
| |
Advertise on this site.
| | |
|
