The role of biotechnology in the production of the anticancer compound podophyllotoxin. Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] Journal article | | Title | The role of biotechnology in the production of the anticancer compound podophyllotoxin. | | Author(s) | Lata H, Mizuno CS, Moraes RM | | Institution | National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS, USA. | | Source | Methods Mol Biol 2009.:387-402. | | MeSH | Antineoplastic Agents, Phytogenic
Biotechnology
Podophyllotoxin
Podophyllum
| | Abstract | Podophyllotoxin is a plant-derived compound found in Podophyllum sp. that is used to produce semi-synthetic anticancer pharmaceuticals such as etoposide, teniposide, and etoposide phosphate. This chapter describes the role of biotechnology to produce podophyllotoxin and our attempts to domesticate Podophyllum peltatum L., also known as the American mayapple. The domestication research on mayapple included surveys of the natural population, identification of high yielding genotypes, propagation, cultivation, sustainable harvest procedures and the development of protocols for in vitro germplasm bank. | | Language | eng | | Pub Type(s) | Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
| | PubMed ID | 19521861 |
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