| Title | Hypericum perforatum extracts healed gastric lesions induced by hypothermic restraint stress in Wistar rats. | | Author(s) | Cayci MK, Dayioglu H | | Institution | Department of Biology, Faculty of Science and Arts, Dumlupinar University, Kutahya, Turkey. kcayci@dumlupinar.edu.tr | | Source | Saudi Med J 2009 Jun; 30(6):750-4. | | MeSH | Animals
Female
Hypericum
Hypothermia
Immobilization
Male
Plant Extracts
Rats
Rats, Wistar
Stomach Ulcer
| | Abstract | OBJECTIVE: To investigate the healing effects of Hypericum perforatum (HP) on gastric mucosal damage induced by hypothermic restraint stress (HRS.
METHODS: Sixty Wistar breed rats of 200-250 gm were used in this study carried out at the Biology Department of Dumlupinar University, Kutahya, Turkey in 2006. The animals were divided into 6 groups, 2 of which were controls. The HRS were induced by strapping the rats on a wooden plank and keeping them for 3 hours at 4 degrees Celsius after a starvation period of 36 hours. After HRS, 25, 50, and 100 mg/kg/day Hypericum perforatum extracts (HPEs) were orally administrated to the 3 groups during the 3-day treatment. Fifty mg/kg ranitidine was administered everyday as subcutaneous injection to a group selected as a positive control. At the end of treatment, lesions in the stomach were evaluated macroscopically and microscopically.
RESULTS: Macroscopic analyses showed that treatment with HPEs 25, 50, and 100 mg/kg/day significantly healed lesions compared to control groups by 65, 95, and 75% (p=0.001). Treatment with ranitidine also healed ulcers significantly compared with the control groups. Histopathologic analyses indicated that 50 mg/kg/day HP produced the most significant effect.
CONCLUSION: Moderate doses of HP produced significant healing of HRS induced gastric ulcer in rats. The present study indicated that HPEs have therapeutic potential for the control of ulcers. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19526154 |
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