| Title | Septic shock induced by Lecythophora mutabilis in a patient with mitochondrial encephalomyopathy. | | Author(s) | Taniguchi Y, Taketani T, Moriyama H, Moriki S, Nishimura K, Sato E, Notsu Y, Higuchi T, Sugitani Y, Yasuda K, Nagai A, Yamaguchi S, Shibata H, Masuda J | | Institution | 1 Central Clinical Laboratory, Shimane University Hospital; | | Source | J Med Microbiol 2009 Jun 15. | | Abstract | Invasive fungal infection (IFI) caused by Lecythophora mutabilis (L. mutabilis) occasionally occurs in patients with impaired host immunity; the patients had eosinophilia at onset, and surviving patients were treated with fungal cell-membrane-targeted drugs. An 18-year-old man with mitochondrial encephalomyopathy accompanied with refractory anemia and chronic renal failure developed septic shock caused by L. mutabilis detected from blood culture. L. mutabilis was identified morphologically and genetically. During the course, he had eosinophilia, although beta-D-glucan levels were within the normal range. He was treated with micafungin, but deteriorated and died, despite changing to liposomal amphotericin B. This suggested that IFI by L. mutabilis should be suspected when a compromised host develops infections with eosinophilia, and that antifungal drugs that target beta-D-glucan are not advisable. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19528157 |
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