Pettit RK, Weber C, Lawrence S, Pettit G, Kean M, Cage G
In vivo activity of anprocide alone, and in vitro activity in combination with conventional antibiotics against Staphylococcus aureus and S. epidermidis biofilms. [JOURNAL ARTICLE]
J Med Microbiol 2009 Jun 15.
The alarming spread of multiple drug resistance in Staphylococcus aureus, combined with the frequent occurrence of S. aureus and S. epidermidis in biofilm-type infections, indicates a growing need for new therapies. The experimental steroidal amide anprocide (3beta-acetoxy-17beta-(L-prolyl)amino-5alpha-androstane) significantly reduced c.f.u. ml-1 suture-1 (p<0.0001) in a murine model of topical S. aureus infection. In checkerboard assays with planktonic-grown S. aureus and S. epidermidis, anprocide was synergistic with bacitracin, oxacillin, clindamycin or ceftriaxone. Anprocide was also synergistic in combination with bacitracin or oxacillin against some isolates of biofilm-grown S. aureus and S. epidermidis.
More from this journal |
