In vivo activity of anprocide alone, and in vitro activity in combination with conventional antibiotics against Staphylococcus aureus and S. epidermidis biofilms. Journal of medical microbiology [J Med Microbiol] Journal article | | Title | In vivo activity of anprocide alone, and in vitro activity in combination with conventional antibiotics against Staphylococcus aureus and S. epidermidis biofilms. | | Author(s) | Pettit RK, Weber C, Lawrence S, Pettit G, Kean M, Cage G | | Institution | 1 Arizona State University; | | Source | J Med Microbiol 2009 Jun 15. | | Abstract | The alarming spread of multiple drug resistance in Staphylococcus aureus, combined with the frequent occurrence of S. aureus and S. epidermidis in biofilm-type infections, indicates a growing need for new therapies. The experimental steroidal amide anprocide (3beta-acetoxy-17beta-(L-prolyl)amino-5alpha-androstane) significantly reduced c.f.u. ml-1 suture-1 (p<0.0001) in a murine model of topical S. aureus infection. In checkerboard assays with planktonic-grown S. aureus and S. epidermidis, anprocide was synergistic with bacitracin, oxacillin, clindamycin or ceftriaxone. Anprocide was also synergistic in combination with bacitracin or oxacillin against some isolates of biofilm-grown S. aureus and S. epidermidis. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19528175 |
|
|
| |
Advertise on this site.
| | |
|
