| Title | Efficacy of combination antifungal therapy of intraperitoneal micafungin with aerosolized liposomal amphotericin B in murine invasive pulmonary aspergillosis. | | Author(s) | Takazono T, Izumikawa K, Mihara T, Kosai K, Saijo T, Imamura Y, Miyazaki T, Seki M, Kakeya H, Yamamoto Y, Yanagihara K, Kohno S | | Institution | Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki University School of Medicine, Nagasaki, Japan; Global Centers of Excellence Programs, Nagasaki University, Nagasaki, Japan; Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. | | Source | Antimicrob Agents Chemother 2009 Jun 15. | | Abstract | Targeted intrapulmonary delivery of drugs may reduce systemic toxicity and improve treatment efficacy. In the current study, we evaluated effects of the combination treatment of aerosolized liposomal amphotericin B (L-AMB) inhalation with intraperitoneal micafungin (MCFG) in murine invasive pulmonary aspergillosis. The combination of aerosolized L-AMB with intraperitoneal MCFG significantly improved survival rate and showed superiority in the fungal burdens and histopathology findings compared to control and both monotherapy groups. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19528281 |
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