| Title | Pathophysiology of Diabetic Nephropathy: Involvement of Multifaceted Signalling Mechanism. | | Author(s) | Balakumar P, Arora MK, Reddy J, Anand-Srivastava MB | | Institution | From the *Department of Physiology, Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada; and daggerCardiovascular Pharmacology Division, ISF College of Pharmacy, Punjab, India. | | Source | J Cardiovasc Pharmacol 2009 Jun 12. | | Abstract | Diabetic nephropathy is a major cause of end-stage renal failure and the mortality rate due to this disease is continuously progressing worldwide. The multifaceted signalling mechanisms have been identified to be involved in the pathogenesis of diabetic nephropathy. Despite the modern therapies like antidiabetics, antihypertensives, and antioxidants available to treat diabetic nephropathy; most of patients continue to show progressive renal damage. It suggests that the key pathogenic mechanism involved in the induction and progression of diabetic nephropathy is still remaining active and unmodified by the present therapies. The purpose of this review is to bring together the current information concerning the signalling systems involved in the pathogenesis of diabetic nephropathy. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19528810 |
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