| Title | Clinical features of familial Mediterranean fever: an Italian overview. | | Author(s) | Manna R, Cerquaglia C, Curigliano V, Fonnesu C, Giovinale M, Verrecchia E, Montalto M, De Socio G, Soriano A, La Regina M, Gasbarrini G | | Institution | Department of Internal Medicine, Catholic University of Sacred Heart, Rome, Italy. rmanna@rm.unicatt.it | | Source | Eur Rev Med Pharmacol Sci 2009 Mar.:51-3. | | Abstract | Familial Mediterranean Fever (FMF) is the most frequent periodic febrile syndrome among the autoinflammatory syndromes (AS), nowadays considered as innate immunity disorders, characterized by absence of autoantibodies and autoreactive T lymphocytes. FMF is a hereditary autosomal recessive disorder, characterized by recurrent, self-limiting episodes of short duration (mean 24e72 h) of fever and serositis. In FMF, periodic attacks show inter- and intra-individual variability in terms of frequency and severity. Usually, they are triggered by apparently innocuous stimuli and may be preceded by a prodromal period. The Mediterranean FeVer gene (MEFV) responsible gene maps on chromosome 16 (16p13) encoding the Pyrine/Marenostrin protein. The precise pathologic mechanism is still to be definitively elucidated; however a new macromolecular complex, called inflammasome, seems to play a major role in the control of inflammation and it might be involved in the pathogenesis of FMF. The most severe long-term complication is type AA amyloidosis, causing chronic renal failure. Two types of risk factors, genetic and non-genetic, have been identified for this complication. Currently, the only effective treatment of FMF is the colchicine. New drugs in a few colchicine resistant patients are under evaluation | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19530512 |
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