Gaynes RP, Gould CV, Edwards J, Antoine TL, Blumberg HM, Desilva K, King M, Kraman A, Pack J, Ribner B, Seybold U, Steinberg J, Jernigan JA
A multicenter study on optimizing piperacillin-tazobactam use: lessons on why interventions fail. [Journal Article, Research Support, U.S. Gov't, P.H.S.]
Infect Control Hosp Epidemiol 2009 Aug; 30(8):794-6.
We examined interventions to optimize piperacillin-tazobactam use at 4 hospitals. Interventions for rotating house staff did not affect use. We could target empiric therapy in only 35% of cases. Because prescribing practices seemed to be institution specific, interventions should address attitudes of local prescribers. Interventions should target empiric therapy and ordering of appropriate cultures.
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