Twice daily fractionated dose administration of prednisolone compared to standard once daily administration to patients with glomerulonephritis or with kidney transplants. Medizinische Klinik (Munich, Germany : 1983) [Med Klin (Munich)] Journal article

Title	Twice daily fractionated dose administration of prednisolone compared to standard once daily administration to patients with glomerulonephritis or with kidney transplants.
Author(s)	Decker SO, Keller F, Mayer J, Stracke S
Institution	Nephrology, Ulm University, Ulm, Germany.
Source	Med Klin (Munich) 2009 Jun 15; 104(6):429-33.
Abstract	BACKGROUND: Pharmacokinetic half-life of prednisolone is 2-3 h, indicating short pharmacodynamic effect duration. Therefore, the fractionated twice daily administration of prednisolone might be favorable. PATIENTS AND METHODS: A 6-month observational study was conducted in a total of 51 patients, 35 with glomerulonephritis and 16 with kidney transplants. Low-dose and long-term prednisolone was given twice daily to 37 patients and once daily to 14 patients. RESULTS: The median dose (first-third quartile) for fractionated prednisolone was 2 x 1.25 mg/day (2.5-2.6) and significantly lower (p = 0.008) than the once daily standard dose of 1 x 4.0 mg/day (2.5-5.0). The number of comedications was also significantly lower in the fractionated dose group: 1.0 co-immunosuppressant (0.0-1.0) compared to 1.5 drugs (0.25-2.0) such as cyclosporine and/or mycophenolate (p = 0.017), and 0.0 antidiabetics (0.0-0.0) versus 0.0 drugs (0.0-0.75) such as gliquidone (p = 0.032). The fall in proteinuria was significant in the fractionated dose group with -0.12 g/l (-0.4-0.0) versus +0.08 g/l (-0.04-+0.24) in controls (p = 0.008). CONCLUSION: Twice daily fractionated administration of prednisolone allows a lower daily dose (total 2.5 mg/day), and appears to be as efficient but less diabetogenic compared to the standard once daily dosing (4.0 mg/day).
Language	eng
Pub Type(s)	Journal Article
PubMed ID	19533049

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