Aripiprazole in L: -dopa-induced dyskinesias: a one-year open-label pilot study. Journal of neural transmission (Vienna, Austria : 1996) [J Neural Transm] Journal article | | Title | Aripiprazole in L: -dopa-induced dyskinesias: a one-year open-label pilot study. | | Author(s) | Meco G, Stirpe P, Edito F, Purcaro C, Valente M, Bernardi S, Vanacore N | | Institution | Centro Parkinson D.A.I. Neurologia e Psichiatria Policlinico Universitario Umberto I degrees , "Sapienza"Università di Roma, Viale dell'Università 30, 00185, Rome, Italy, giuseppe.meco@uniroma1.it. | | Source | J Neural Transm 2009 May 12. | | Abstract | Aripiprazole is a novel antipsychotic medication characterized by partial agonism at the D2 and 5-HT1A receptors and by antagonism at the 5-HT2A receptor. The aim of the present study was to evaluate, in an open-label pilot study, the effects and safety of very small doses of aripiprazole on L: -dopa-induced dyskinesia of a group of PD patients who did not show a significant clinical benefit by pharmacological treatment with amantadine and mirtazapine. Twelve PD patients with peak-dose LID were enrolled in a period of 1 year. Aripiprazole dosage was of 0.625 mg/day. The ten patients who continued taking aripiprazole displayed a significant decrease in the intensity and frequency of dyskinesias in all parts of the body, particularly in trunk movements (AIMS score T (0) = 14.1 +/- 3.6 vs. final score 2.4. +/- 2.6; P = 0.005). Our study suggests that aripiprazole at very low doses is tolerated and could be efficacy in treating LID. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19533295 |
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