| Title | Methicillin-resistant Staphylococcus aureus (MRSA): identification and susceptibility testing techniques. | | Author(s) | Reygaert W | | Institution | Oakland University, School of Health Sciences, Medical Laboratory Science Program, Rochester, Michigan 48309, USA. reygaert@oakland.edu | | Source | Clin Lab Sci 2009; 22(2):120-4. | | Abstract | Many traditional techniques are useful for identification of MRSA strains, including techniques for detection of penicillin-resistance, such as the nitrocefin disk. Techniques for assessing methicillin-resistance vary from growth on special media or at a lower temperature, to detection of the mecA gene by manual (latex agglutination) and automated (PCR) methods. Technique development is now geared toward making MRSA identification more rapid. Real-time PCR has sped MRSA detection, but can be costly. Resistance to other drugs is also an issue. Clindamycin resistance may need to be induced, so a special disk diffusion test can be performed. Vancomycin resistance is becoming an issue, so alternative drugs need to be identified. Drugs that are currently available for MRSA infections include: daptomycin, linezolid, quinupristin/dalfopristin, and tigecycline. Drugs that are in the development phase include: ceftobiprole, dalbavancin, oritavancin, and telavancin. These drugs provide a promising arsenal against MRSA. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19534447 |
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