| Title | The Modern Spectrum of Rhabdomyolysis: Drug Toxicity Revealed by Creatine Kinase Screening. | | Author(s) | Linares L, Golomb B, Jaojoco J, Sikand H, Phillips PS | | Institution | Internal Medicine Resident, Scripps Mercy Hospital, San Diego, CA 92103, USA. Phillips.Paul@scrippshealth.org. | | Source | Curr Drug Saf 2009 Sep 1. | | Abstract | Purpose: This study describes the current etiologies, demographic characteristics, incidence of acute renal insufficiency and correlation between peak creatine kinase (CK) and peak creatinine in hospitalized patients with rhabdomyolysis.
Methods: A retrospective chart review of patients with creatine kinase (CK) values greater than 5000 IU/L during a nine month period identified 106 cases of rhabdomyolysis.
Results: The most common contributing etiologies were recreational drug and/or alcohol use in 28%, trauma in 23%, compression in 19%, shock in 17%, statin-use in 13%, seizure in 8% and quetiapine-use in 8%. 37% of cases involved multiple etiologies. Renal insufficiency occurred in 49% of cases and modestly but significantly correlated with CK (R2 = 0.41, p %lt; 0.0001). Myoglobinuria and a pre-renal state were associated with renal insufficiency in 49% and 52% of cases, respectively.
Conclusions: Rhabdomyolysis should be defined with CK values exceeding 10-25 times the upper limit of normal irrespective of renal function. Using a laboratory marker such as CK can aid diagnosis of rhabdomyolysis and identify adverse drug events. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19534642 |
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