| Title | Tigecycline susceptibility report from an Indian tertiary care hospital. | | Author(s) | Behera B, Das A, Mathur P, Kapil A, Gadepalli R, Dhawan B | | Institution | Department of Laboratory Medicine, Jai Prakash Narayan Apex Trauma Centre, New Delhi, India. | | Source | Indian J Med Res 2009 Apr; 129(4):446-50. | | Abstract | BACKGROUND & OBJECTIVE: Treatment of serious life threatening infections due to multi-drug resistant pathogens presents a difficult challenge due to the limited therapeutic options. Therefore, we studied the in vitro susceptibility of tigecycline, a new glycylcycline with promising broad spectrum of activity against Gram positive and Gram negative bacteria at a tertiary care hospital in north India.
METHODS: A total of 75 multi-drug resistant isolates of methicillin resistant Staphylococcus aureus (21), vancomycin resistant enterococci (14), vancomycin resistant Streptococcus spp. (3), extended spectrum beta lactamase producing Gram negative bacteria (11) and multi-resistant Acinetobacter spp. (26) were tested for tigecycline susceptibility by the E-test and disc diffusion methods. An additional 83 multi-resistant Gram negative clinical isolates were screened by disc diffusion method alone.
RESULTS: All the isolates of MRSA, VRE, vancomycin resistant Streptococcus spp. and ESBL producing enteric bacteria were sensitive to tigecycline by the E-test and disc diffusion methods. However, only 42 per cent of Acinetobacter spp. were found to be sensitive to tigecycline by the E-test method.
INTERPRETATION & CONCLUSION: In conclusion, tigecycline was found to be highly effective against Gram-positive bacteria and Gram-negative members of Enterobacteriaceae, but a high prevalence of resistance in members of Acinetobacter spp. is worrisome. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19535842 |
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