| Title | Amantadine-resistant influenza A (H3N2) viruses in Iran. | | Author(s) | Yavarian J, Mokhtari Azad T, Shafiei Jandaghi NZ, Nategh R | | Source | Acta Virol 2009; 53(2):135-8. | | Abstract | Adamantanes have been used for the prophylaxis and treatment of Influenza A virus (IAV) infections worldwide. However, they have limited use because of increasing number of resistant viruses during recent years. In investigating the frequency of amantadine-resistant IAVs (H3N2) circulating in Iran in 2005-2008, we found that M2 sequences of recently circulating viruses that were amantadine-resistant contained a Ser31Asn mutation. Thus, adamantanes should not be used for treatment or prophylaxis of recent IAVs (H3N2) infections. In future, their potential use will depend on the resistance of circulating viruses. Keywords: Influenza A (H3N2) virus; amantadine; resistance; Iranian isolates. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19537916 |
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