| Title | Effects of anserine on the renal sympathetic nerve and blood pressure in urethane-anesthetized rats. | | Author(s) | Tanida M, Shen J, Kubomura D, Nagai K | | Institution | College of Life Sciences, Ritsumeikan University, Kusatsu, Shiga, Japan. mtanida@sk.ritsumei.ac.jp. | | Source | Physiol Res 2009 Jun 19. | | Abstract | Previous studies have demonstrated that central injection of L-carnosine (beta-alynyl-L-histidine), dipeptide synthesized in mammalian muscles, affects renal sympathetic nerve activity (RSNA) and blood pressure (BP) in anesthetized rats. In the present study, using urethane-anesthetized rats, we examined the dose-dependent effects of intravenous (IV) injection of various doses of anserine, dipeptide of similar structure to L-carnosine, on RSNA, BP and heart rate (HR). We found that injection of a low dose of anserine (1 microg) suppressed RSNA, BP and HR significantly. Conversely, a high dose (1000 microg) of anserine elevated RSNA, BP and HR significantly. Pretreatment with intralateral cerebral ventricular (LCV) injection of thioperamide, a histaminergic H3-receptor antagonist, eliminated the effects of a low dose of anserine on RSNA, BP and HR. LCV injection of diphenhydramine, a histaminergic H1-receptor antagonist, abolished the effects of a high dose of anserine on RSNA, BP and HR. These findings suggest that anserine affects RSNA, BP and HR in a dose-dependent manner, and that the histaminergic nerve may be involved in the dose-different effects of anserine in rats. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19537934 |
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