Yoshikawa Y, Hirata R, Yasui H, Sakurai H
Alpha-glucosidase Inhibitory Effect of Anti-diabetic Metal Ions and Their Complexes. [JOURNAL ARTICLE]
Biochimie 2009 Jun 15.
We found alpha-glucosidase inhibitory (alpha-GI) effect of metal ions and their complexes which showed the high blood glucose lowering effect in diabetic model animals. The Cu(II) ion and its complexes showed strong alpha-GI activity greater than clinically used acarbose in in vitro studies. Furthermore, in in vivo experiments, alpha-GI action was newly discovered in normal ddy mice. These results suggested that one of action mechanisms of the anti-diabetic metal ions and complexes is related to the alpha-GI effects.
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