| Title | Alpha-glucosidase Inhibitory Effect of Anti-diabetic Metal Ions and Their Complexes. | | Author(s) | Yoshikawa Y, Hirata R, Yasui H, Sakurai H | | Institution | Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University, 5 Nakauchi-cho, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan. | | Source | Biochimie 2009 Jun 15. | | Abstract | We found alpha-glucosidase inhibitory (alpha-GI) effect of metal ions and their complexes which showed the high blood glucose lowering effect in diabetic model animals. The Cu(II) ion and its complexes showed strong alpha-GI activity greater than clinically used acarbose in in vitro studies. Furthermore, in in vivo experiments, alpha-GI action was newly discovered in normal ddy mice. These results suggested that one of action mechanisms of the anti-diabetic metal ions and complexes is related to the alpha-GI effects. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19539008 |
|
