Allogeneic hematopoietic stem cell transplantation recipients have defects of both switched and igm memory B cells. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation [Biol Blood Marrow Transplant] Journal article | | Title | Allogeneic hematopoietic stem cell transplantation recipients have defects of both switched and igm memory B cells. | | Author(s) | D'Orsogna LJ, Wright MP, Krueger RG, McKinnon EJ, Buffery SI, Witt CS, Staples N, Loh R, Cannell PK, Christiansen FT, French MA | | Institution | Department of Clinical Immunology and Immunogenetics, Royal Perth Hospital and PathWest Laboratory Medicine, Perth, Australia. | | Source | Biol Blood Marrow Transplant 2009 Jul; 15(7):795-803. | | MeSH | Adult
Antibodies, Bacterial
Antigens, CD19
Antigens, CD27
B-Lymphocytes
CD4-Positive T-Lymphocytes
Cross-Sectional Studies
Female
Gene Rearrangement, B-Lymphocyte
Graft vs Host Disease
Hematopoietic Stem Cell Transplantation
Humans
Immunoglobulin A
Immunoglobulin G
Immunoglobulin M
Immunologic Memory
Male
Middle Aged
Polysaccharides, Bacterial
Retrospective Studies
Streptococcus pneumoniae
Transplantation, Homologous
| | Abstract | Allogeneic hematopoietic stem cell transplant (HSCT) recipients were assessed to elucidate memory B cell defects underlying their increased susceptibility to infections, particularly by encapsulated bacteria. Circulating IgM memory B cells (CD19+, CD27+, IgM+) and switched memory B cells (CD19+, CD27+, IgM(-)) were enumerated in allogeneic HSCT recipients (n = 37) and healthy controls (n = 35). T lymphocyte subpopulations and serum levels of immunoglobulins, including IgG subclasses, and antibodies to pneumococcal polysaccharides were also assayed. Allogeneic HSCT recipients were deficient in both switched memory and IgM memory B cells compared to healthy controls (both P < .0001), irrespective of time post-HSCT. Switched memory B cell deficiency correlated with CD4+ T cell deficiency, and both correlated with serum levels of IgG1 (P < .0001), possibly reflecting impaired B cell isotype switching in germinal centres. "Steady-state" serum levels of antibodies to pneumococcal polysaccharides did not correlate with circulating memory B cells. Graft-versus-host disease (GVHD) was associated with lower IgM memory B cell counts and lower serum levels of IgG2, IgG4, IgA, and pneumococcal antibodies. The increased susceptibility of allogeneic HSCT patients to infection may reflect a combination of memory B cell defects, which are most common in patients with a history of GVHD. | | Language | eng | | Pub Type(s) | Comparative Study
Journal Article
| | PubMed ID | 19539210 |
|
|
| |
Advertise on this site.
| | |
|
