| Title | Antidepressant-like effects of glucagon-like peptide-2 in mice occur via monoamine pathways. | | Author(s) | Iwai T, Hayashi Y, Narita S, Kasuya Y, Jin K, Tsugane M, Oka JI | | Institution | Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, 278-8510, Japan. | | Source | Behav Brain Res 2009 Jun 16. | | Abstract | In this study, we investigated whether glucagon-like peptide-2 (GLP-2) had antidepressant-like effects in mice, and whether these activities were associated with monoamine systems in mice. Antidepressant-like effects were evaluated based on the immobility time in the forced-swim test. GLP-2 (1.5-6mug/mouse, i.c.v.) significantly reduced the immobility time in a dose-dependent manner without affecting locomotor activity in the wheel running test and memory function in the step-down passive avoidance test. These effects were inhibited by pretreatment with metergoline (an antagonist of non-specific 5-HT receptors), parachlorophenylalanine (an inhibitor of 5-HT synthase), NAN-190 (an antagonist of 5-HT(1A) receptors), yohimbine hydrochloride (an antagonist of alpha(2) adrenoceptors), atenolol (an antagonist of beta(1) receptors), and raclopride (an antagonist of D(2) receptors), but not prazosin (an antagonist of alpha(1) adrenoceptors), ICI118551 (an antagonist of beta(2) adrenoceptors), and SCH23394 (an antagonist of D(1) receptors). These results suggest that GLP-2 exerts antidepressant-like effects in the forced-swim test in mice that are associated with 5-HT(1A), alpha(2), beta(1) and D(2) receptors. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19539656 |
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