| Title | Substrate specificity of lipase from Burkholderia cepacia in the synthesis of 3'-arylaliphatic acid esters of floxuridine. | | Author(s) | Li N, Zeng QM, Zong MH | | Institution | State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou 510640, China; Laboratory of Applied Biocatalysis, College of Light Industry and Food Sciences, South China University of Technology, Guangzhou 510640, China. | | Source | J Biotechnol 2009 Jun 16. | | Abstract | Among the five vinyl esters bearing phenyl ring in acyl moiety, the lipase from Burkholderia cepacia was most specific toward vinyl 4-phenylbutyrate. Additionally, 3'-regioselectivity of the enzyme was enhanced with the increment of acyl chain length. The lipophilic 3'-arylaliphatic acid esters of floxuridine, its potential prodrugs, were synthesized with high conversions (>98%) and good to excellent regioselectivities (85-99%) via the enzymatic approach. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19539679 |
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