Thotala D, Chetyrkin S, Hudson B, Hallahan D, Voziyan P, Yazlovitskaya E
Pyridoxamine protects intestinal epithelium from ionizing radiation-induced apoptosis. [JOURNAL ARTICLE]
Free Radic Biol Med 2009 Jun 18.
Reactive oxygen species (ROS) and reactive carbonyl species (RCS) are the major cause of biological tissue damage during the exposure to ionizing radiation (IR). The existing strategies to protect normal tissues from detrimental effects of IR suffer from several shortcomings including high toxic side effects, unfavorable administration routs or low efficacy. These shortcomings emphasize a need for radioprotective treatments that combine effectiveness with safety and ease of use. In this paper, we demonstrate that pyridoxamine, a ROS and RCS scavenger with a very favorable safety profile, can inhibit IR-induced gastrointestinal endothelial apoptosis in cell culture and in animal model. Pyridoxamine was more effective at protecting from radiation-induced apoptosis compared to Amifostine, a synthetic thiol compound and the only FDA approved radioprotector. We suggest that PM has a potential as an effective and safe radioprotective agent.
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