Borie R, Wislez M, Thabut G, Antoine M, Rabbat A, Couderc LJ, Monnet I, Nunes H, Blanc FX, Mal H, Bergeron A, Dusser D, Israël-Biet D, Crestani B, Cadranel J
Clinical characteristics and prognostic factors of pulmonary MALT lymphoma. [JOURNAL ARTICLE]
Eur Respir J 2009 Jun 18.
MALT lymphoma, a low grade B-cell extranodal lymphoma, is the most frequent subset of primary pulmonary lymphoma. Our objective was to evaluate the initial extent of disease and to analyze the characteristics and long-term outcome of these patients.All chest and pathological departments of teaching hospitals in Paris were contacted to identify patients with a histological diagnosis of primary pulmonary lymphoma of the MALT subtype.Sixty-three cases were identified. The median age was 60 years. Thirty-six percent of cases had no symptoms at diagnosis. Forty-six percent of patients had at least one extra-pulmonary location of lymphoma. The estimated 5- and 10-year overall survival rates were 90% and 72%, respectively. Only two of the nine observed deaths were related to lymphoma. Age and performance-status were the only 2 adverse prognostic factors for survival. Extra-pulmonary location of lymphoma was not a prognostic factor for overall survival nor progression-free survival. Treatment with cyclophosphamide or anthracyclin was associated with shorter progression-free survival, when compared to chlorambucil.The survival data confirm the indolent nature of pulmonary MALT lymphoma. Better progression-free survival was observed with chlorambucil when compared to cyclophosphamide or anthracyclin.
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