| Title | Elevated Serum Uric Acid Concentrations Independently Predict Cardiovascular Mortality In Type 2 Diabetic Patients. | | Author(s) | Zoppini G, Targher G, Negri C, Stoico V, Perrone F, Muggeo M, Bonora E | | Institution | From the Section of Endocrinology, Department of Biomedical and Surgical Sciences, University of Verona, Verona, Italy. | | Source | Diabetes Care 2009 Jun 19. | | Abstract | Objective - There is limited information on whether increased serum uric acid levels are independently associated with cardiovascular mortality in type 2 diabetes. We assessed the predictive role of serum uric acid levels on all-cause and cardiovascular mortality in a large cohort of type 2 diabetic individuals. Research Design and Methods - The cohort included 2,726 type 2 diabetic outpatients, who were followed for a mean period of 4.7 years. The independent association of serum uric acid levels with all-cause and cardiovascular mortality was assessed by Cox proportional-hazards models and adjusted for conventional risk factors and several potential confounders. Results - During follow-up, 329 (12.1%) patients died, 44.1% (n=145) of whom for cardiovascular causes. In univariate analysis, higher serum uric acid levels were significantly associated with increased risk of all-cause (hazard ratio [HR] 1.19, 95% confidence intervals 1.12-1.27, p<0.001) and cardiovascular (HR 1.25, 1.16-1.34, p<0.001) mortality. After adjustment for age, gender, body mass index, smoking, hypertension, dyslipidemia, diabetes duration, hemoglobin A1c, medications use (allopurinol, hypoglycemic, anti-hypertensive, lipid-lowering and anti-platelet drugs), estimated glomerular filtration rate and albuminuria, the association of serum uric acid with cardiovascular mortality remained statistically significant (HR 1.27, 1.01-1.61, p=0.046), whereas the association of serum uric acid with all-cause mortality did not. Conclusions - Higher serum uric acid levels are associated with increased risk of cardiovascular mortality in type 2 diabetic patients, independently of several potential confounders, including renal function measures. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19542211 |
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