Lansoprazole, Ranitidine, and Metoclopramide: Comparison of Practice Patterns at 4 Level III NICUs Within One Healthcare System. Advances in neonatal care : official journal of the National Association of Neonatal Nurses [Adv Neonatal Care] Journal article | | Title | Lansoprazole, Ranitidine, and Metoclopramide: Comparison of Practice Patterns at 4 Level III NICUs Within One Healthcare System. | | Author(s) | Barney CK, Baer VL, Scoffield SH, Lambert DK, Cook M, Christensen RD | | Institution | 1Intermountain Healthcare, McKay-Dee Hospital Center, Ogden, Utah. | | Source | Adv Neonatal Care 2009 Jun; 9(3):129-31. | | Abstract | PURPOSE: Evidence is needed to guide NICU use of lansoprazole (Prevacid), ranitidine (Zantac), and metoclopramide (Reglan). As a step toward that goal, we conducted a historic cohort analysis of all patients who received any of these medications in 4 Intermountain Healthcare NICUs during the year 2006.
SUBJECTS: Data were obtained from all patients admitted between January 1 and December 31, 2006, to any of 4 Intermountain Healthcare NICUs.
DESIGN: This was a retrospective descriptive design.
METHODS: Data were obtained from electronic pharmacy records and electronic medical records. The NICUs involved were blinded and included McKay-Dee Hospital Center, Ogden, Utah; LDS Hospital, Salt Lake City, Utah; Utah Valley Regional Medical Center, Provo, Utah; and Dixie Regional Medical Center, St George, Utah.
RESULTS: Although the demographics of the patients at the 4 centers were similar, significant differences were seen among the centers in drug use patterns. Lansoprazole use ranged from a high of 17% of patients in one center to a low of 7% of patients in another. Ranitidine use ranged from 9% in one center to 1% in another. Metoclopramide use ranged from 9% of patients in one center to <1% in another.
CONCLUSIONS: The extreme variability among the centers in use patterns of these 3 medications suggests lack of an adequate evidence base to guide practice and indicates that case controlled studies or random controlled trials are needed to devise a consistent evidence-based approach. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19542776 |
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